MIT Technology Review highlights nine biotech innovators under 35
MIT Technology Review’s latest 35 Innovators Under 35 list includes nine biotech researchers. Five are profiled, working on postpartum hemorrhage, brain electrodes, personalized gene editing, age-reversal eye therapy and AI-designed bacteriophages.
Paschal Kija, 28, developed Mkanda Salama, or Safe Wrap in Swahili, to treat postpartum hemorrhage. The device is easy to use and costs $70. A study found it stopped postpartum bleeding in 73% of women within 20 minutes. In Kija’s home country, Tanzania, the complication contributes to around 29% of maternal deaths, according to MIT Technology Review.
Xiao Yang, 34, is working on ultra-small, flexible brain electrodes that she hopes will have less impact on surrounding brain tissue than existing devices. The electrodes resemble actual neurons, and Yang is also creating sheets of electrodes to study brain cells in the lab. Inspired by kirigami, the traditional Japanese art of cutting paper to form three-dimensional shapes, she built a honeycombed sheet of electrodes shaped like a spiral basket and is using it to study brain cells.
Sarah Grandinette, 26, was part of a team that developed a personalized gene-editing therapy for Kyle 'KJ' Muldoon Jr., who was born in 2024 with a rare and potentially fatal genetic disorder. Grandinette created cells with KJ’s genetic variant to screen gene-editing approaches, then tested potential medicines in mice and monkeys. KJ received his first dose when he was about seven months old, responded well and was eventually discharged from hospital. Grandinette says he is 'doing pretty great.'
Yuancheng (Ryan) Lu, 34, and colleagues published a 2020 study showing that a reprogramming therapy reversed vision loss in aged, blind mice. An almost identical version of that therapy is now being tested in people with eye disease. Life Biosciences, the company developing the drug, dosed its first volunteer in June.
Samuel King, 27, used a generative AI model to design new genetic blueprints for bacteriophages, tiny viruses that infect bacteria. He printed the blueprints as strands of DNA. In experiments, the AI-designed viruses could create new copies of themselves, burst out of bacterial cells and infect nearby bacteria, MIT Technology Review reported. King hopes AI-designed life forms might one day be used to make drugs or soak up pollution.
MIT Technology Review said the list includes nine biotech innovators in total. The annual 35 Innovators Under 35 list recognizes people whose research and technical work stands to shape the future of their fields.